{"id":9,"date":"2019-03-19T18:46:16","date_gmt":"2019-03-19T09:46:16","guid":{"rendered":"https:\/\/nishi-lab.bs.teu.ac.jp\/?page_id=9"},"modified":"2020-04-23T17:07:00","modified_gmt":"2020-04-23T08:07:00","slug":"%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9","status":"publish","type":"page","link":"https:\/\/nishi-lab.bs.teu.ac.jp\/?page_id=9","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u6211\u3005\u3092\u69cb\u6210\u3059\u308b\u3082\u3068\u306b\u306a\u308b\u907a\u4f1d\u60c5\u5831\u304c\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u30b2\u30ce\u30e0DNA\u306f\u5b89\u5b9a\u306b\u7dad\u6301\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u30b2\u30ce\u30e0DNA\u306f\u69d8\u3005\u306a\u8981\u56e0\u3001\u4f8b\u3048\u3070\u7d2b\u5916\u7dda\u306a\u3069\u306e\u5916\u7684\u306a\u8981\u56e0\u3084DNA\u8907\u88fd\u306e\u30a8\u30e9\u30fc\u306a\u3069\u306e\u5185\u7684\u306a\u8981\u56e0\u3001\u306b\u3088\u308a\u5e38\u306b\u50b7\uff08DNA\u640d\u50b7\uff09\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\uff08\u56f31\uff09\u3002\u751f\u7269\u306f\u591a\u69d8\u306aDNA\u4fee\u5fa9\uff08DNA repair\uff09\u6a5f\u69cb\u306b\u3088\u308a\u3001\u30bf\u30a4\u30d7\u306e\u7570\u306a\u308bDNA\u640d\u50b7\u3092\u4fee\u5fa9\u3057\u3001DNA\u640d\u50b7\u306b\u8d77\u56e0\u3059\u308b\u6709\u5bb3\u306a\u4e8b\u8c61\u3092\u9632\u3044\u3067\u3044\u307e\u3059\u3002\u767a\u751f\u3057\u305fDNA\u640d\u50b7\u304c\u4fee\u5fa9\u3055\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3084\u3001\u4e0d\u9069\u5207\u306a\u4fee\u5fa9\u304c\u884c\u308f\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u7d30\u80de\u6b7b\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u304c\u8a98\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001DNA\u4fee\u5fa9\u6a5f\u69cb\u304c\u751f\u7269\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/nishi-lab.bs.teu.ac.jp\/wp-content\/uploads\/2020\/04\/\u56f31.png\" alt=\"\" class=\"wp-image-145\"\/><\/figure><\/div>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u56f31.&nbsp;\u69d8\u3005\u306aDNA\u640d\u50b7\u3068DNA\u4fee\u5fa9\u6a5f\u69cb\u306e\u5f79\u5272<\/p>\n\n\n\n<p style=\"font-size:18px\" class=\"has-text-color has-very-dark-gray-color\"><strong>\u7814\u7a76\u30c6\u30fc\u30de1:&nbsp;\u6838\u5185\u69cb\u9020\u4f53\u3068DSB\u4fee\u5fa9\u6a5f\u69cb\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306e\u89e3\u660e<\/strong><\/p>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001DNA\u640d\u50b7\u306e\u3046\u3061\u96fb\u96e2\u653e\u5c04\u7dda\u3084\u6297\u304c\u3093\u5264\u7b49\u306b\u3088\u308a\u751f\u3058\u308bDNA\u4e8c\u91cd\u9396\u5207\u65ad\uff08DNA double-strand breaks:&nbsp;DSBs\uff09\u306e\u4fee\u5fa9\u6a5f\u69cb\u3092\u4e3b\u306b\u30d2\u30c8\u7d30\u80de\u3092\u7528\u3044\u3066\u89e3\u660e\u3059\u308b\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002DSB\u306fDNA\u3092\u69cb\u6210\u3059\u308b\uff12\u672c\u306e\u9396\u304c\u4e21\u65b9\u3068\u3082\u5207\u65ad\u3055\u308c\u308b\u5f62\u306eDNA\u640d\u50b7\u3067\u3042\u308a\u3001DNA\u640d\u50b7\u306e\u3046\u3061\u6700\u3082\u91cd\u7be4\u306a\u3082\u306e\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u96fb\u96e2\u653e\u5c04\u7dda\u3084\u6297\u304c\u3093\u5264\u306b\u3088\u3063\u3066\u767a\u751f\u3059\u308bDSB\u306e\u4fee\u5fa9\u6a5f\u69cb\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066\u306e\u307fDSB\u4fee\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u3001\u3088\u308a\u52b9\u679c\u7684\u30fb\u5b89\u5168\u306a\u304c\u3093\u6cbb\u7642\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08\u56f32\uff09\u3002\u307e\u305f\u3001DSB\u4fee\u5fa9\u6a5f\u69cb\u306e\u7834\u7dbb\u304c\u767a\u304c\u3093\u3092\u4f34\u3046\u907a\u4f1d\u6027\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001DSB\u4fee\u5fa9\u6a5f\u69cb\u306e\u7406\u89e3\u306f\u767a\u304c\u3093\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/nishi-lab.bs.teu.ac.jp\/wp-content\/uploads\/2020\/04\/\u56f32.png\" alt=\"\" class=\"wp-image-146\"\/><\/figure><\/div>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u56f32. DSB\u4fee\u5fa9\u306e\u7406\u89e3\u306b\u57fa\u3065\u304f\u304c\u3093\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/p>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u6211\u3005\u306e\u7814\u7a76\u3092\u542b\u3081\u3001\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306e\u7814\u7a76\u304b\u3089DSB\u4fee\u5fa9\u306e\u57fa\u672c\u7684\u306a\u5206\u5b50\u6a5f\u69cb\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u6838\uff08\u7d30\u80de\u6838\uff09\u306b\u306f\u6838\u5c0f\u4f53\u3001nuclear speckles\u306a\u3069\u306e\u6838\u5185\u69cb\u9020\u4f53\uff08nuclear bodies\u3042\u308b\u3044\u306fnuclear structures\u3068\u547c\u3070\u308c\u308b\uff09\u304c\u5b58\u5728\u3057\u3001\u30b2\u30ce\u30e0DNA\u306e\u6838\u5185\u3067\u306e\u5206\u5e03\u3084\u907a\u4f1d\u5b50\u767a\u73fe\u306a\u3069\u306e\u6a5f\u80fd\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u6838\u5185\u69cb\u9020\u4f53\u304cDSB\u4fee\u5fa9\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\uff08\u56f33\uff09\u3002\u6211\u3005\u306f\u6838\u5185\u69cb\u9020\u4f53\u306e\u306a\u304b\u3067\u3082\u8ee2\u5199\u30fb\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3055\u308c\u308bnuclear speckles\u304cDSB\u4fee\u5fa9\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/nishi-lab.bs.teu.ac.jp\/wp-content\/uploads\/2020\/04\/\u56f33.png\" alt=\"\" class=\"wp-image-147\"\/><\/figure>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u56f33.&nbsp;\u7d30\u80de\u6838\u5185\u306b\u304a\u3044\u3066\u30b2\u30ce\u30e0DNA\u306f\u6838\u5185\u69cb\u9020\u4f53\u3068\u6df7\u5728\u3057\u3066\u3044\u308b<\/p>\n\n\n\n<p style=\"font-size:18px\" class=\"has-text-color has-very-dark-gray-color\"><strong>\u7814\u7a76\u30c6\u30fc\u30de2:&nbsp;\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308bDSB\u4fee\u5fa9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/p>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u307e\u305f\u3001\u6211\u3005\u306e\u7d30\u80de\u5185\u3067\u6a5f\u80fd\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u69d8\u3005\u306a\u5f62\u3067\u6a5f\u80fd\u5236\u5fa1\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u7ffb\u8a33\u5f8c\u4fee\u98fe\uff08post-translational modifications: PTMs\uff09\u306f\u305d\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u3067\u3059\u3002PTM\u306b\u306f\u30ea\u30f3\u9178\u5316\u3001\u30a2\u30bb\u30c1\u30eb\u5316\u3084\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306a\u3069\u304c\u3042\u308a\u3001\u6975\u3081\u3066\u591a\u304f\u306e\u7d30\u80de\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002DSB\u4fee\u5fa9\u3082\u4f8b\u5916\u3067\u306f\u306a\u304f\u3001\u3053\u308c\u3089\u306ePTM\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u53b3\u5bc6\u306a\u6a5f\u80fd\u5236\u5fa1\u306b\u3088\u3063\u3066\u8abf\u548c\u306e\u3068\u308c\u305f\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306ePTM\u306e\u91cd\u8981\u306a\u7279\u5fb4\u3068\u3057\u3066\u53ef\u9006\u7684\u306a\u53cd\u5fdc\u3067\u3042\u308b\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001PTM\u306e\u4ed8\u52a0\u3042\u308b\u3044\u306f\u3001\u9664\u53bb\u306b\u3088\u308a\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5fc5\u8981\u306a\u6642\u306b\u306e\u307f\u6d3b\u6027\u5316\u3055\u305b\u305f\u308a\u3001\u7d30\u80de\u5185\u306e\u7279\u5b9a\u306e\u90e8\u4f4d\u3078\u52d5\u54e1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u6211\u3005\u306f\u3053\u308c\u3089\u306ePTM\u306e\u3046\u3061\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u7740\u76ee\u3057\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308bDSB\u4fee\u5fa9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306f\u5f53\u521d\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306b\u3088\u308b\u5206\u89e3\u306b\u5c0e\u304f\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u4eca\u3067\u306f\u305d\u308c\u306b\u52a0\u3048\u3066\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3068\u3057\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u524d\u8ff0\u3057\u305f\u3088\u3046\u306b\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306f\u53ef\u9006\u7684\u306a\u53cd\u5fdc\u3067\u3042\u308a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u306e\u4ed8\u52a0\uff08\u30e2\u30ce\u3001\u30de\u30eb\u30c1\u53ca\u3073\u30dd\u30ea\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304c\u5b58\u5728\u3059\u308b\uff09\u3067\u306fE1\u3001E2\u3001E3\u3068\u547c\u3070\u308c\u308b\u9175\u7d20\u304c\u6a5f\u80fd\u3059\u308b\u4e00\u65b9\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306e\u9664\u53bb\uff08\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3068\u3088\u3070\u308c\u308b\uff09\u306f\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20\uff08deubiquitylating enzymes: DUBs\uff09\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\uff08\u56f34\uff09\u3002\u3064\u307e\u308a\u3001DSB\u4fee\u5fa9\u304c\u6b63\u3057\u304f\u6a5f\u80fd\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3068\u8131\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304c\u9069\u5207\u306a\u5834\u6240\u3001\u6642\u671f\u306b\u304a\u3044\u3066\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8a00\u3048\u307e\u3059\u3002\u6211\u3005\u306fDSB\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308bDUB\u3092\u540c\u5b9a\u3001\u6a5f\u80fd\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308bDSB\u4fee\u5fa9\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/nishi-lab.bs.teu.ac.jp\/wp-content\/uploads\/2020\/04\/\u56f34-1.png\" alt=\"\" class=\"wp-image-165\"\/><\/figure>\n\n\n\n<p class=\"has-text-color has-normal-font-size has-very-dark-gray-color\">\u56f34.\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u5236\u5fa1<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6211\u3005\u3092\u69cb\u6210\u3059\u308b\u3082\u3068\u306b\u306a\u308b\u907a\u4f1d\u60c5\u5831\u304c\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u30b2\u30ce\u30e0DNA\u306f\u5b89\u5b9a\u306b\u7dad\u6301\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u30b2\u30ce\u30e0DNA\u306f\u69d8\u3005\u306a\u8981\u56e0\u3001\u4f8b\u3048\u3070\u7d2b\u5916\u7dda\u306a\u3069\u306e\u5916\u7684\u306a\u8981\u56e0\u3084DNA\u8907\u88fd\u306e\u30a8\u30e9\u30fc\u306a\u3069\u306e\u5185\u7684\u306a\u8981\u56e0\u3001\u306b\u3088\u308a\u5e38\u306b\u50b7\uff08DNA\u640d\u50b7 &#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":24,"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":216,"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/216"}],"wp:attachment":[{"href":"https:\/\/nishi-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}