研究業績

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原著論文 (Peer-reviewed)

  1. Mizuho Okamoto, Masanori Shimogishi, Akari Nakamura, Yusuke Suga, Kyosuke Sugawara, Michio Sato, Ryotaro Nishi, Akiko Fujisawa, Yorihiro Yamamoto and Misato Kashiba, Differentiation of THP-1 monocytes to macrophages increased mitochondrial DNA copy number but did not increase expression of mitochondrial respiratory proteins or mitochondrial transcription factor A, Archives of Biochemistry and Biophysics, 2021, 15, 108988
  2. Misaki Matsui, Ryo Sakasai, Masako Abe, Yusuke Kimura, Shoki Kajita, Wakana Torii, Yoko Katsuki, Masamichi Ishiai, Kuniyoshi Iwabuchi, Minoru Takata and Ryotaro Nishi*, USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9, Oncogenesis, 2020, 9, 60, *Corresponding author
  3. Ryotaro Nishi*, Paul W. G. Wijnhoven, Yusuke Kimura, Misaki Matsui, Rebecca Konietzny, Qian Wu, Keisuke Nakamura, Tom L. Blundell, and Benedikt M. Kessler, The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage, Scientific Reports,2018, 8, 17891,*Corresponding author
  4. Ryotaro Nishi. Balancing act: To be, or not to be ubiquitylated. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 803-805, 43-50, 2017
  5. Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai, and Kaoru Sugasawa, Thymine DNA glycosylase modulates the DNA damage response and gene expression by base excision repair-dependent and -independent mechanisms. Genes to Cells, 22 (4), 392-405, 2017
  6. Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano and Atsushi Shibata. BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation. Cell Reports, 18 (2), 520-532, 2017
  7. Paul Wijnhoven, Rebecca Konietzny, Andrew N. Blackford, Jonathan Travers, Benedikt M. Kessler, Ryotaro Nishi* and Stephen P. Jackson*. USP4 Auto-Deubiquitylation Promotes Homologous Recombination. Molecular Cell, 60 (3), 362-373, 2015, *Corresponding authors
  8. Masaki Akita, Yon-Soo Tak, Tsutomu shimura, Syota Matsumoto, Yuki Okuda-Shimizu, Yuichiro Shimizu, Ryotaro Nishi, Hisato Saitoh, Shigenori Iwai, Toshio Mori, Tsuyoshi Ikura, Wataru Sakai, Fumio Hanaoka and Kaoru Sugasawa. SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair. Scientific Reports, 5, 10984, 2015
  9. Syota Matsumoto, Eric S. Fisher, Takeshi Yasuda, Naoshi Dohmae, Shigenori Iwai, Toshio Mori, Ryotaro Nishi, Ken-ichi Yoshino, Wataru Sakai, Fumio Hanaoka, Nicolas H, Thomä and Kaoru Sugasawa. Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein. Nucleic Acids Research, 43 (3), 1700-1713, 2015
  10. Ryotaro Nishi, Paul Wijnhoven, Carlos le Sage, Jorrit Tjeertes, Yaron Galanty, Josep V. Forment, Michael J. Clague, Sylvie Urbé and Stephen P Jackson. Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nature Cell Biology, 16 (10), 1016-1026, 2014
  11. Ryotaro Nishi*, Wataru Sakai*, Daisuke Tone, Fumio Hanaoka and Kaoru Sugasawa. Structure-function analysis of the EF-hand protein centrin-2 for its intracellular localization and nucleotide excision repair. Nucleic Acids Research, 41 (14), 6917-6929, 2013 *; equally contributing author
  12. Niina Tanaka, Miki Goto, Azusa Kawasaki, Takashi Sasano, Ko Eto, Ryotaro Nishi, Kaoru Sugasawa, Shinichi Abe and Hisato Saitoh. An EF-hands protein, centrin-1, is an EGTA-sensitive SUMO-interacting protein in mouse testis. Cell Biochemistry and Function, 28 (7), 604-612, 2010
  13. Kaoru Sugasawa, Jun-ichi Akagi, Ryotaro Nishi, Shigenori Iwai and Fumio Hanaoka. Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Molecular Cell, 36 (4), 642-653, 2009
  14. Ryotaro Nishi, Sergey Alekseev, Christoffel Dinant, Deborah Hoogstraten, Adriaan B. Houtsmuller, Jan H. J. Hoeijmakers, Wim Vermeulen, Fumio Hanaoka and Kaoru Sugasawa. UV-DDB dependent regulation of nucleotide excision repair kinetics in living cells. DNA Repair, 8 (6), 767-776, 2009
  15. Gentaro Yasuda*, Ryotaro Nishi*, Eriko Watanabe, Toshio Mori, Shigenori Iwai, Donata Orioli, Miria Stefanini, Fumio Hanaoka, and Kaoru Sugasawa. In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation. Molecular and Cellular Biology, 27 (19), 6606-6614, 2007 *; equally contributing author
  16. Ryotaro Nishi, Yuki Okuda, Eriko Watanabe, Toshio Mori, Shigenori Iwai, Chikahide Masutani, Kaoru Sugasawa, and Fumio Hanaoka. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Molecular and Cellular Biology, 25 (13), 5664-5674, 2005
  17. Kaoru Sugasawa, Yuki Okuda, Masafumi Saijo, Ryotaro Nishi, Noriyuki Matsuda, Gilbert Chu, Toshio Mori, Shigenori Iwai, Keiji Tanaka, Kiyoji Tanaka, and Fumio Hanaoka. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell,121 (3), 387-400, 2005
  18. Yuki Okuda, Ryotaro Nishi, Jessica M.Y. Ng, Wim Vermeulen, Gijsbertus T.J. van der Horst, Toshio Mori, Jan H.J. Hoeijmakers, Fumio Hanaoka and Kaoru Sugasawa. Relative levels of the two mammalian Rad23 homologs determine and stability of the xeroderma pigmentosum group C protein complex. DNA Repair, 3 (10), 1285-1295, 2004

日本語総説

  1. 西　良太郎、「DNA二重鎖切断応答を制御する脱ユビキチン化酵素群」、放生研ニュース、2016
  2. 西　良太郎、「DNA損傷応答にH1リンカーヒストンが関与していた！」、実験医学、2016、Vol. 34, No. 4, 2月
  3. 西　良太郎, 菅澤　薫　紫外線によるDNA損傷の修復機構 蛋白質核酸酵素, 51, 2126-2133, 2006, 11

学会発表（招待講演のみ表示）

  1. Ryotaro Nishi, DNA二本鎖切断修復と核内構造体のクロストークの解明, Genome Damage Network, Kyoto, 2019/03/11-12
  2. Misaki Matsui, Yusuke Kimura, Masako Abe, Syoki Kajita, Wakana Torii, Masamichi Ishiai, Minoru Takata and Ryotaro Nishi, 新規nuclear speckle因子USP42は相同組換え修復を制御する, 日本放射線影響学会第61回大会, 長崎, 2018/11/07
  3. Ryotaro Nishi, タンパク質ユビキチン化の時空間的制御から紐解くDNA二重鎖切断修復機構, 日本放射線影響学会第61回大会, 長崎, 2018/11/08
  4. 松井 美咲, 木村祐輔, 安倍昌子, 石合正道, 堀利行, 高田穰, Stephen P Jackson, 西良太郎, 核内構造体に局在する因子による相同組換え修復制御, 第40回日本分子生物学会年会（2017年度生命科学系学会合同年次大会）, 神戸, 2017/12 /06-09
  5. Ryotaro Nishi, Paul Wijnhoven, Yusuke Kimura, Misaki Matsui, Keisuke Nakamura, Rebecca Konietny, Qian Wu, Toshiyuki Hori, Tom Blundell, Benedikt M Kessler and Stephen P Jackson, A deubiquitylating enzyme, UCHL3, enhances non-homologous end-joining by regulating Ku ubiquitylation, The 33rd International Symposium of Radiation Biology Center, Hotel Co-op Inn Kyoto, Kyoto, 2017/12/04-05
  6. 松井 美咲, 木村祐輔, 安倍昌子, 石合正道, 堀利行, 高田穰, Stephen P Jackson, 西良太郎, 核内構造体によるDNA二本鎖切断応答制御機構の解明, 日本放射線影響学会第60回大会, 千葉, 2017/10/25-28
  7. 西　良太郎, Ubiquitin carboxyl-terminal hydrolase familyによるDNA二重鎖切断応答制御機構, 平成29年度専門研究会　若手放射線生物研究会主催, 東京, 2017/09/02-03
  8. Ryotaro Nishi, Yusuke Kimura, Misaki Matsui and Stephen P Jackson, DNA double-strand break repair and responses regulated by UCH family deubiquitylating enzymes, 日本放射線影響学会第59回大会, 広島, 2016/10/26-28
  9. Ryotaro Nishi, DNA double-strand break repair and responses regulated by UCH family deubiquitylating enzymes, The 32rd RBC International Symposium “Growing Edge of Radiation Biology, from principles to applications., Coop-Inn Kyoto, Kyoto, 2016/09/01-02
  10. Paul Wijnhoven, Rebecca Konietzny, Andrew N. Blackford, Jonathan Travers, Benedikt M. Kessler, Ryotaro Nishi* and Stephen P. Jackson*, DNA二重鎖切断修復に関与する脱ユビキチン化酵素を介したゲノム安定性維持機構, BMB2015, 第38回日本分子生物学会年会, 第88回日本生化学大会合同大会, 神戸, 2015/12/03
  11. Ryotaro Nishi, 脱ユビキチン化酵素によるDNA二重鎖切断修復制御機構, 放射線影響学会放射線ワークショップ〜未来に繋ぐ放射線研究〜, 富山, 2015/10/16
  12. Ryotaro Nishi, Paul Wijnhoven, Carlos le Sage, Jorrit Tjeertes, Yaron Galanty, Josep V. Forment, Michael J. Clague, Sylvie Urbé and Stephen P Jackson, 脱ユビキチン化酵素によるDNA二重鎖切断応答の制御機構, 群馬大学第２回Genome Damage Discussion Group公開セミナー, 群馬、2015/6/29
  13. Ryotaro Nishi, Paul Wijnhoven, Carlos le Sage, Jorrit Tjeertes, Yaron Galanty, Josep V. Forment, Michael J. Clague, Sylvie Urbé and Stephen P Jackson, DUB-mediated regulation of DNA double-strand break repair, Cambridge Cell Cycle Club, University of Cambridge, United Kingdom, 2015/02/26
  14. Ryotaro Nishi, Paul Wijnhoven, Carlos le Sage, Jorrit Tjeertes, Yaron Galanty, Josep V. Forment, Michael J. Clague, Sylvie Urbé and Stephen P Jackson, Systematic characterization of deubiquitylating enzymes in DNA double-strand break repair, Cambridge 3R seminar series, Cambridge LMB, United Kingdom, 2014
  15. Ryotaro Nishi, Sergey Alekseev, Christoffel Dinant, Deborah Hoogstraten, Adriaan B. Houtsmuller, Jan H. J. Hoeijmakers, Wim Vermeulen, Fumio Hanaoka and Kaoru Sugasawa, ヌクレオチド除去修復因子の細胞内動態とその制御機構の解析, The 30th Annual Meeting of the Molecular Biology Society of Japan, Yokohama, Japan, 2007/12/13
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